I've had a look at three shows so far and I think I'll be keeping two of them, in addition to Soul Eater from spring.
Mahou Tsukai ni Taisetsu na Koto ~Natsu no Sora~ is about a girl who goes to Tokyo for mage training. The backgrounds are simply stunning and the animation is just as quality. The pacing seems really slow, but I think it wouldn't hurt to keep on following it, and I get some pretty art to look at.
Natsume Yuujinchou is about a boy who can see spirits. His grandmother was also able to see spirits and she managed to defeat a whole bunch of them and keep their names in a book. So, now he's going to return those names so that the spirits are freed and go away. This looks like it will turn out fairly decently.
World Destruction is about a group of adventurers who try to destroy the world. It's based on the DS RPG by Sega. I was initially drawn to it expecting Yasunori Mitsuda's music, but found that he's only doing music for the game. Otherwise, the anime seems like a fairly typical video game tie-in. I'm not sure if I'm going to keep it.
So what's everyone else picking up this season?